Open AccessFriend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer
Author(s) -
Chen Shaohua,
Zhang Daohai
Publication year - 2015
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2015.01.004
Subject(s) - endoplasmic reticulum , unfolded protein response , microbiology and biotechnology , morphogenesis , secretion , metastasis , secretory protein , cancer cell , suppressor , biology , chaperone (clinical) , cancer research , cell , cancer , pathology , medicine , gene , biochemistry , genetics
The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as “friend or foe” in epithelial cancer.