Open AccessThe di‐peptide Trp‐His activates AMP‐activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes
Author(s) -
Soga Minoru,
Ohashi Ayaka,
Taniguchi Megumi,
Matsui Toshiro,
Tsuda Takanori
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.10.008
Subject(s) - glut4 , ampk , protein kinase a , glucose transporter , chemistry , glucose uptake , insulin , microbiology and biotechnology , medicine , peptide , amp activated protein kinase , endocrinology , biochemistry , kinase , biology
These findings indicate that (1) WH activates AMPK and insulin independently enhances glucose uptake following translocation of Glut4 to the plasma membrane, (2) activation of AMPKα by WH is mediated by the LKB1 pathway, without altering the Ca 2+ ‐dependent pathway, and (3) L6 myotubes express only one type of peptide transporter (PHT1; SLC15a4), which incorporates WH into cells to activate AMPKα.