Open AccessA new pma1 mutation identified in a chronologically long‐lived fission yeast mutant
Author(s) -
Naito Chikako,
Ito Hirokazu,
Oshiro Tomoko,
Ohtsuka Hokuto,
Murakami Hiroshi,
Aiba Hirofumi
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.09.006
Subject(s) - schizosaccharomyces pombe , mutant , yeast , fission , mutation , schizosaccharomyces , biology , life span , genetics , saccharomyces cerevisiae , gene , evolutionary biology , physics , quantum mechanics , neutron
We isolated a chronologically long‐lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1 + that encoded for an essential P‐type proton ATPase. An Asp‐138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission yeast. This study corroborates our previous report indicating Pma1 activity is crucial for the determination of life span of fission yeast, and offers information for better understanding of the enzyme, Pma1.