Open AccessIs there a link between proprotein convertase PC7 activity and human lipid homeostasis?
Author(s) -
Guillemot Johann,
Essalmani Rachid,
Hamelin Josée,
Seidah Nabil G.
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.08.004
Subject(s) - medicine , endocrinology , pcsk9 , apolipoprotein b , proprotein convertase , ldl receptor , kexin , chemistry , biology , lipoprotein , cholesterol
A genome‐wide association study suggested that a R504H mutation in the proprotein convertase PC7 is associated with increased circulating levels of HDL and reduced triglycerides in black Africans. Our present results show that PC7 and PC7‐R504H exhibit similar processing of transferrin receptor‐1, proSortilin, and apolipoprotein‐F. Plasma analyses revealed no change in the lipid profiles, insulin or glucose of wild type and PC7 KO mice. Thus, the R504H mutation does not modify the proteolytic activity of PC7. The mechanisms behind the implication of PC7 in the regulation of human HDL, triglycerides and in modifying the levels of atherogenic small dense LDL remain to be elucidated.