Open AccessDiffusion weighted MRI of mediastinal masses: Can measurement of ADC value help in the differentiation between benign and malignant lesions
Author(s) -
Amin M. Nasr,
Hazem Mohamed Elshahat,
Hadeer K. Safwat,
Rand F Alsaif,
Derrar Alshehab,
Mohamed Shebl
Publication year - 2016
Publication title -
the egyptian journal of radiology and nuclear medicine /the egyptian journal of radiology and nuclear medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 13
eISSN - 2090-4762
pISSN - 0378-603X
DOI - 10.1016/j.ejrnm.2015.12.002
Subject(s) - medicine , radiology , effective diffusion coefficient , diffusion mri , histopathology , lesion , nuclear medicine , magnetic resonance imaging , pathology
Purpose: The purpose of this study is to evaluate the role of measurement of ADC value in the differentiation between benign and malignant mediastinal lesions.Patients and methods: 42 patients with 52 mediastinal lesions were included in this study. They underwent diffusion weighted MRI with b values of 1000 and 0 s/mm2. ADC value measurement and histopathological diagnosis were done for each lesion. Correlation between ADC value and histopathology was done through statistical analysis.Results: 32 lesions were malignant and 20 lesions were benign. The mean ADC value for the malignant lesions was significantly lower than the mean ADC value for benign lesions (P value <0.001). The mean ADC value for malignant lesions was 0.91 ± 0.23 × 10−3 mm2/s while for the benign lesions it was 1.80 ± 0.55 × 10−3 mm2/s. The cutoff point of the ADC value differentiating malignant from benign mediastinal lesions was 1.15 × 10−3 mm2/s with sensitivity of 95%, specificity of 93.8%, positive predictive value of 90.5%, and negative predictive value of 96.8% and accuracy of 94.4%.Conclusion: Diffusion weighted MRI and measurement of ADC value are very helpful in the differentiation between benign and malignant mediastinal lesions