The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile | Zendy

Hshieh Tammy T. | Zendy; Vasunilashorn Sarinnapha M. | Zendy; D'Aquila Madeline L. | Zendy; Arnold Steven E. | Zendy; Dickerson Bradford C. | Zendy; Fong Tamara G. | Zendy; Jones Richard N. | Zendy; Kunze Lisa J. | Zendy; Vlassakov Kamen V. | Zendy; Abdeen Ayesha R. | Zendy; Lange Jeffrey K. | Zendy; Earp Brandon E. | Zendy; Travison Thomas G. | Zendy; Inouye Sharon K. | Zendy; Arnold Steven | Zendy; Dickerson Bradford | Zendy; Fong Tamara | Zendy; Jones Richard | Zendy; Libermann Towia A. | Zendy; Marcantonio Edward R. | Zendy; Travison Thomas | Zendy; Carlyle Becky C. | Zendy; Cavallari Michele | Zendy; Dillon Simon T. | Zendy; Hooker Jacob | Zendy; Hshieh Tammy | Zendy; Kandigian Savannah | Zendy; KivisakkWebb Pia | Zendy; Ngo Long | Zendy; Otu Hasan | Zendy; Schmitt Eva M. | Zendy; Touroutoglou Alexandra | Zendy; Trombetta Bianca | Zendy; Vasunilashorn Sarinnapha | Zendy; Abdeen Ayesha | Zendy; Ayres Douglas | Zendy; Earp Brandon | Zendy; Lange Jeffrey | Zendy; Brick Gregory | Zendy; Chen Antonia | Zendy; Davis Robert | Zendy; Drew Jacob | Zendy; Iorio Richard | Zendy; Kornack Fulton | Zendy; Weaver Michael | Zendy; Webber Anthony | Zendy; Wilk Richard | Zendy; Kunze Lisa | Zendy; Shaff David | Zendy; Vlassakov Kamen | Zendy; Armstrong Brett | Zendy; Banda Angelee | Zendy; Bertrand Sylvie | Zendy; D'Aquila Madeline | Zendy; Gallagher Jacqueline | Zendy; Hightower Baileigh | Zendy; Malloy Shan | Zendy; Nee Jacqueline | Zendy; Nobuhara Chloe | Zendy; Overstreet Abigail | Zendy; Racine Annie | Zendy; Urick David | Zendy; Xu Guoquan | Zendy; Arabasz Grae | Zendy; Brickhouse Michael | Zendy; Butterfield Regan | Zendy; Hsu Shirley | Zendy; Makaretz Sara | Zendy; Sore Judit | Zendy; Chen Fan | Zendy; Gou Yun | Zendy; Tommet Douglas | Zendy; Carretie Sabrina | Zendy; Gruen Ted | Zendy; Tasker Katherine | Zendy

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The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

Author(s) -

Hshieh Tammy T.,

Vasunilashorn Sarinnapha M.,

D'Aquila Madeline L.,

Arnold Steven E.,

Dickerson Bradford C.,

Fong Tamara G.,

Jones Richard N.,

Marcantonio Edward R.,

Schmitt Eva M.,

Xu Guoquan,

Gou Yun,

Chen Fan,

Kunze Lisa J.,

Vlassakov Kamen V.,

Abdeen Ayesha R.,

Lange Jeffrey K.,

Earp Brandon E.,

Touroutoglou Alexandra,

Carlyle Becky C.,

KivisakkWebb Pia,

Travison Thomas G.,

Dillon Simon T.,

Libermann Towia A.,

Inouye Sharon K.,

Arnold Steven,

Dickerson Bradford,

Fong Tamara,

Jones Richard,

Libermann Towia A.,

Marcantonio Edward R.,

Travison Thomas,

Carlyle Becky C.,

Cavallari Michele,

Dillon Simon T.,

Hooker Jacob,

Hshieh Tammy,

Kandigian Savannah,

KivisakkWebb Pia,

Ngo Long,

Otu Hasan,

Schmitt Eva M.,

Touroutoglou Alexandra,

Trombetta Bianca,

Vasunilashorn Sarinnapha,

Abdeen Ayesha,

Ayres Douglas,

Earp Brandon,

Lange Jeffrey,

Brick Gregory,

Chen Antonia,

Davis Robert,

Drew Jacob,

Iorio Richard,

Kornack Fulton,

Weaver Michael,

Webber Anthony,

Wilk Richard,

Kunze Lisa,

Shaff David,

Vlassakov Kamen,

Armstrong Brett,

Banda Angelee,

Bertrand Sylvie,

D'Aquila Madeline,

Gallagher Jacqueline,

Hightower Baileigh,

Malloy Shan,

Nee Jacqueline,

Nobuhara Chloe,

Overstreet Abigail,

Racine Annie,

Urick David,

Xu Guoquan,

Arabasz Grae,

Brickhouse Michael,

Butterfield Regan,

Hsu Shirley,

Makaretz Sara,

Sore Judit,

Chen Fan,

Gou Yun,

Tommet Douglas,

Carretie Sabrina,

Gruen Ted,

Tasker Katherine

Publication year - 2019

Publication title -

alzheimer's and dementia: diagnosis, assessment and disease monitoring

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.497

H-Index - 37

ISSN - 2352-8729

DOI - 10.1016/j.dadm.2019.09.004

Subject(s) - medicine , delirium , cerebrospinal fluid , prospective cohort study , positron emission tomography , cohort , inflammation , biomarker , cohort study , arthroplasty , surgery , radiology , biochemistry , chemistry , intensive care medicine

The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [ 11 C]‐PBR28 positron‐emission tomography imaging. Methods This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty‐five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini‐Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron‐emission tomography with detailed clinical characterization of delirium, cognition, and functional status.

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