Open AccessThe Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study
Author(s) -
Weaver Nick A.,
Zhao Lei,
Biesbroek J. Matthijs,
Kuijf Hugo J.,
Aben Hugo P.,
Bae HeeJoon,
Caballero Miguel Á.A.,
Chappell Francesca M.,
Chen Christopher P.L.H.,
Dichgans Martin,
Duering Marco,
Georgakis Marios K.,
Giessen Ruben S.,
Gyanwali Bibek,
Hamilton Olivia K.L.,
Hilal Saima,
Hofe Elise M.,
Kort Paul L.M.,
Koudstaal Peter J.,
Lam Bonnie Y.K.,
Lim JaeSung,
Makin Stephen D.J.,
Mok Vincent C.T.,
Shi Lin,
Valdés Hernández Maria C.,
Venketasubramanian Narayanaswamy,
Wardlaw Joanna M.,
Wollenweber Frank A.,
Wong Adrian,
Xin Xu,
DeCarli C.,
Fletcher E.A.,
Maillard P.,
Barnes J.,
Sudre C.H.,
Schott J.M.,
Ikram M.A.,
Papma J.M.,
Steketee R.M.E.,
Vernooij M.W.,
Bordet R.,
Lopes R.,
Huang C.W.,
Frayne R.,
McCreary C.R.,
Smith E.E.,
Backes W.,
Köhler S.,
Oostenbrugge R.J.,
Staals J.,
Verhey F.,
Cheng C.Y.,
Kalaria R.N.,
Werring D.,
Hsu J.L.,
Huang K.L.,
Grond J.,
Jukema J.W.,
Mast R.C.,
Nijboer T.C.W.,
Yu K.H.,
Schmidt R.,
Pirpamer L.,
MacIntosh B.J.,
Robertson A.D.,
Leeuw F.E.,
Tuladhar A.M.,
Chaturvedi N.,
Tillin T.,
Brodaty H.,
Sachdev P.,
Barkhof F.,
Flier W.M.,
Kappelle L.J.,
Biessels Geert Jan
Publication year - 2019
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2019.02.007
Subject(s) - hyperintensity , lesion , cognition , medicine , stroke (engine) , population , meta analysis , magnetic resonance imaging , radiology , psychology , surgery , psychiatry , mechanical engineering , environmental health , engineering
The Meta VCI Map consortium performs meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion‐symptom mapping studies. Methods Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results Forty‐seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population‐based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.