Open AccessUtility of perfusion PET measures to assess neuronal injury in Alzheimer's disease
Author(s) -
JosephMathurin Nelly,
Su Yi,
Blazey Tyler M.,
Jasielec Mateusz,
Vlassenko Andrei,
Friedrichsen Karl,
Gordon Brian A.,
Hornbeck Russ C.,
Cash Lisa,
Ances Beau M.,
Veale Thomas,
Cash David M.,
Brickman Adam M.,
Buckles Virginia,
Cairns Nigel J.,
Cruchaga Carlos,
Goate Alison,
Jack Clifford R.,
Karch Celeste,
Klunk William,
Koeppe Robert A.,
Marcus Daniel S.,
Mayeux Richard,
McDade Eric,
Noble James M.,
Ringman John,
Saykin Andrew J.,
Thompson Paul M.,
Xiong Chengjie,
Morris John C.,
Bateman Randall J.,
Benzinger Tammie L.S.
Publication year - 2018
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2018.08.012
Subject(s) - positron emission tomography , nuclear medicine , pittsburgh compound b , perfusion , fluorodeoxyglucose , alzheimer's disease , medicine , perfusion scanning , dementia , psychology , disease
18 F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11 C‐Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB‐R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross‐sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results Metabolism and perfusion images were spatially correlated. Regional PiB‐R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion Hypometabolism estimated by PiB‐R1 may provide a measure of brain perfusion without increasing radiation exposure.