Open AccessLower cerebral blood flow in subjects with Alzheimer's dementia, mild cognitive impairment, and subjective cognitive decline using two‐dimensional phase‐contrast magnetic resonance imaging
Author(s) -
Leijenaar Jolien F.,
Maurik Ingrid S.,
Kuijer Joost P.A.,
Flier Wiesje M.,
Scheltens Philip,
Barkhof Frederik,
Prins Niels D.
Publication year - 2017
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1016/j.dadm.2017.10.001
Subject(s) - cerebral blood flow , magnetic resonance imaging , dementia , medicine , cardiology , cognition , cognitive decline , cohort , alzheimer's disease , cognitive impairment , psychology , audiology , disease , radiology , psychiatry
Abstract Introduction In this cross‐sectional study, we aimed to detect differences in cerebral blood flow (CBF) between subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD), using two‐dimensional phase‐contrast magnetic resonance imaging. Methods We included 74 AD patients (67 years, 51% female), 36 MCI patients (66 years, 33% female), and 62 patients with SCD (60 years, 32% female) from the Amsterdam Dementia Cohort. Patients with SCD are those who visited the memory clinic with subjective cognitive complaints without objective cognitive impairment. Whole‐brain CBF (mL/100 g/min) was calculated using total volume flow measured with two‐dimensional phase‐contrast magnetic resonance imaging and normalized for brain volume. Results Mean CBF values (SD) were lower in AD compared to SCD (age and sex adjusted 70 ± 26 vs. 82 ± 24 mL/100 g/min, P < .05). Mean CBF values of MCI were comparable to AD. Across clinical groups, lower CBF was associated with lower scores on the Mini–Mental State Examination (age and sex adjusted stβ = 0.19 per mL/100 g/min; P = .02). Discussion Lower whole‐brain CBF is seen in AD patients compared to SCD patients and is associated with worse cognitive function.