Open AccessNebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice
Author(s) -
Kinga K. Borowicz-Reutt,
Monika Banach,
Monika Rudkowska
Publication year - 2019
Publication title -
pharmacological reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.706
H-Index - 83
eISSN - 2299-5684
pISSN - 1734-1140
DOI - 10.1007/s43440-019-00029-6
Subject(s) - nebivolol , carbamazepine , phenobarbital , pharmacology , phenytoin , anticonvulsant , medicine , anesthesia , epilepsy , chemistry , psychiatry , blood pressure
Due to co-occurrence of seizures and cardiovascular disorders, nebivolol, a widely used selective β 1 -blocker with vasodilatory properties, may be co-administered with antiepileptic drugs. Therefore, we wanted to assess interactions between nebivolol and four conventional antiepileptic drugs: carbamazepine, valproate, phenytoin and phenobarbital in the screening model of tonic-clonic convulsions.
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