Open AccessRETRACTED ARTICLE: Stem Cell Mediated Tooth Regeneration: New Vistas in Dentistry
Author(s) -
M Sujesh,
V. Rangarajan,
C Ravi Kumar,
G. Sunil Kumar
Publication year - 2011
Publication title -
the journal of indian prosthodontic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 20
eISSN - 1998-4057
pISSN - 0972-4052
DOI - 10.1007/s13191-011-0110-9
Subject(s) - stem cell , crown (dentistry) , dentistry , regeneration (biology) , embryonic stem cell , dentin , enamel paint , orthodontics , biology , medicine , microbiology and biotechnology , biochemistry , gene
The generation of dental structures and/or entire teeth in the laboratory depends upon the manipulation of stem cells and requires a synergy of all cellular and molecular events that finally lead to the formation of tooth-specific hard tissues, dentin and enamel. This review focuses on the different sources of stem cells that have been used for making teeth in vitro and their relative efficiency. Embryonic, post-natal and adult stem cells were assessed and proved to possess an enormous regenerative potential, but their application in dental practice is still limited due to various parameters that are not yet under control such as the high risk of rejection, cell behaviour, long tooth eruption period, appropriate crown morphology and suitable colour. Nevertheless, the development of biological approaches for dental reconstruction using stem cells is promising and remains one of the greatest challenges in the dental field.