Open AccessBiopsy Examination Validity Based on Narrow Band Imaging Guidance of Nasopharyngeal Carcinoma Suspected Patients
Author(s) -
Slamet Suwondo,
Bakti Surarso,
Iwan Kristyono
Publication year - 2018
Publication title -
indian journal of otolaryngology and head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 2231-3796
pISSN - 0973-7707
DOI - 10.1007/s12070-018-1324-5
Subject(s) - mcnemar's test , medicine , nasopharyngeal carcinoma , biopsy , radiology , histopathology , otorhinolaryngology , kappa , positive predicative value , pathology , predictive value , radiation therapy , surgery , linguistics , statistics , philosophy , mathematics
The diagnosis of nasopharyngeal carcinoma (NPC) is established based on histopathological examination results of tumor tissue in nasopharynx and narrow band imaging (NBI) which is an imaging technique that utilizes specific displacement and light absorption characteristics of a specific wavelength. It has not known yet the validity of nasopharyngeal biopsy examination results based on NBI guidance and blind biopsy as a golden standard in establishing nasopharyngeal carcinoma diagnosis. Analyzing the validity of the nasopharyngeal biopsy examination results through NBI guidance and blind biopsy as a golden standard in nasopharyngeal carcinoma diagnosis. NPC patients performed biopsy using NBI then performed blind biopsy and the results of both examinations were analyzed. Histopathologic examination results of blind biopsy were 23 samples with NPC positive (52.3%) and 21 samples with NPC negative (47.7%). On histopathology examination using NBI guidance 34 samples (77.3%) were positive malignant cells and 10 samples (22.7%) were negative malignant cells. It was calculated and obtained the following results; sensitivity = 95.7%, specificity = 42.9%, positive predictive value = 64.7%, negative predictive value = 90.0%, and accuracy = 70%. Furthermore, statistical analysis using McNemar comparative test and Kappa association test were performed. In McNemar comparative test obtained p value = 0.003 and in Kappa association test obtained p value = 0.002. Histopathologic biopsy examination results using NBI guidance were only valid in stage IV NPC compared to blind biopsy.