Open AccessConnexin Gap Junctions and Hemichannels Link Oxidative Stress to Skeletal Physiology and Pathology
Author(s) -
Rui Hua,
Jingruo Zhang,
Manuel A. Riquelme,
Jean X. Jiang
Publication year - 2021
Publication title -
current osteoporosis reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.472
H-Index - 57
eISSN - 1544-2241
pISSN - 1544-1873
DOI - 10.1007/s11914-020-00645-9
Subject(s) - connexin , oxidative stress , osteocyte , microbiology and biotechnology , oxidative phosphorylation , gap junction , mechanotransduction , biology , chemistry , endocrinology , osteoblast , biochemistry , intracellular , in vitro
The goal of this review is to provide an overview of the impact and underlying mechanism of oxidative stress on connexin channel function, and their roles in skeletal aging, estrogen deficiency, and glucocorticoid excess associated bone loss.