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Sex‐and age‐related differences in ceramide dihexosides of primary human brain tumors
Author(s) -
Yates Allan J.,
Franklin Teresa K.,
Scheithauer Berndt W.,
Burger Peter C.,
Pearl Dennis K.
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-999-330-7
Subject(s) - lipidology , ceramide , clinical chemistry , primary (astronomy) , brain tumor , neurochemistry , medicine , psychology , biology , neurology , endocrinology , physiology , genetics , neuroscience , pathology , apoptosis , physics , astronomy
Neutral glycolipids (NGL) are promising diagnostic markers of human gliomas, but differences in NGL with age and sex have not been examined. Previous work demonstrated that ceramide dihexosides (CDH) levels in mouse kidney are age‐ and sex‐dependent, probably due to levels of sex hormones. We quantitated CDH in 181 human gliomas and found significant differences with sex and age, particularly menopause and male puberty. This emphasizes the importance of assessing results of studies on glycolipids in disease states with respect to age and sex in order to avoid erroneous conclusions concerning the relationship of glycolipid composition with diagnosis and pathogenesis.