Open AccessIntraoperative radiotherapy (IORT) for surgically resected brain metastases: outcome analysis of an international cooperative study
Author(s) -
Christopher P. Cifarelli,
Stefanie Brehmer,
John A. Vargo,
Joshua Hack,
Klaus Henning Kahl,
Gustavo R. Sarria,
Frank A. Giordano
Publication year - 2019
Publication title -
journal of neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.256
H-Index - 114
eISSN - 1573-7373
pISSN - 0167-594X
DOI - 10.1007/s11060-019-03309-6
Subject(s) - medicine , radiosurgery , retrospective cohort study , surgery , radiation therapy , intraoperative radiotherapy , radiology , cancer , breast cancer
The ideal delivery of radiation to the surgical cavity of brain metastases (BMs) remains the subject of debate. Risks of local failure (LF) and radiation necrosis (RN) have prompted a reappraisal of the timing and/or modality of this critical component of BM management. IORT delivered at the time of resection for BMs requiring surgery offers the potential for improved local control (LC) afforded by the elimination of delay in time to initiation of radiation following surgery, decreased uncertainty in target delineation, and the possibility of dose escalation beyond that seen in stereotactic radiosurgery (SRS). This study provides a retrospective analysis with identification of potential predictors of outcomes.