Open AccessExamination and prognostic implications of the unique microenvironment of breast cancer brain metastases
Author(s) -
Maria J. Sambade,
Grace Prince,
Allison M. Deal,
Dimitri G. Trembath,
Megan Jean McKee,
Amy Garrett,
Kevin Keith,
Jorge A. Ramı́rez,
Bentley R. Midkiff,
Kimberly Blackwell,
Sarah Sammons,
José Pablo Leone,
Adam Brufsky,
Aki Morikawa,
Edi Brogi,
Andrew D. Seidman,
Matthew G. Ewend,
Lisa A. Carey,
Stergios J. Moschos,
Ronald L. Hamilton,
Benjamin G. Vincent,
Carey K. Anders
Publication year - 2019
Publication title -
breast cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.908
H-Index - 154
eISSN - 1573-7217
pISSN - 0167-6806
DOI - 10.1007/s10549-019-05211-1
Subject(s) - gliosis , medicine , breast cancer , immune system , pathology , cancer , context (archaeology) , triple negative breast cancer , oncology , immunology , biology , paleontology
Brain metastases (BM) are a complication of advanced breast cancer (BC). Histology of melanoma BM offers prognostic value; however, understanding the microenvironment of breast cancer brain metastases (BCBM) is less characterized. This study reports on four histological biomarkers, gliosis, immune infiltrate, hemorrhage, necrosis, and their prognostic significance in BCBM.