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Golgi post‐translational modifications and associated diseases
Author(s) -
Potelle Sven,
Klein André,
Foulquier François
Publication year - 2015
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1007/s10545-015-9851-7
Subject(s) - golgi apparatus , transmembrane protein , secretory pathway , secretion , organelle , cytoplasm , microbiology and biotechnology , biology , compartment (ship) , computational biology , endoplasmic reticulum , biochemistry , receptor , oceanography , geology
For non specialists, Golgi is a very well known subcellular compartment involved in secretion and correct targeting of soluble and transmembrane proteins. Nevertheless, Golgi is also specifically involved in many different and diverse post‐translational modifications. Through its diverse functions, Golgi is not only able to modify secreted and transmembrane proteins but also cytoplasmic proteins. The Golgi apparatus research field is so broad that an exhaustive review of this organelle is not doable here. The goal of this review is to cover the main post‐translational modifications occurring at the Golgi level and present the identified associated diseases.