Open AccessEffects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution
Author(s) -
Ali Gheidi,
Lora M. Cope,
Christopher Fitzpatrick,
Benjamin Froehlich,
Rachel L. Atkinson,
Coltrane K. Groves,
Clair N. Barcelo,
Jonathan D. Morrow
Publication year - 2020
Publication title -
psychopharmacology/psychopharmacologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.378
H-Index - 196
eISSN - 1432-2072
pISSN - 0033-3158
DOI - 10.1007/s00213-020-05571-3
Subject(s) - infralimbic cortex , cannabinoid , cannabinoid receptor , neuroscience , endocannabinoid system , psychology , agonist , incentive salience , nucleus accumbens , prefrontal cortex , dopamine , receptor , medicine , cognition
Pavlovian conditioned approach paradigms are used to characterize the nature of motivational behaviors in response to stimuli as either directed toward the cue (i.e., sign-tracking) or the site of reward delivery (i.e., goal-tracking). Recent evidence has shown that activity of the endocannabinoid system increases dopaminergic activity in the mesocorticolimbic system, and other studies have shown that sign-tracking behaviors are dependent on dopamine.