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Synthetic Access to Derivatized Mn‐Pyane as a Redox‐modulated Pool of SODm
Author(s) -
Scheitler Andreas,
Friedel Felix,
Puchta Ralph,
DückerBenfer Carlos,
IvanovićBurmazović Ivana
Publication year - 2018
Publication title -
zeitschrift für anorganische und allgemeine chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.354
H-Index - 66
eISSN - 1521-3749
pISSN - 0044-2313
DOI - 10.1002/zaac.201800140
Subject(s) - redox , manganese , ring (chemistry) , pyridine , chemistry , superoxide dismutase , catalysis , stereochemistry , combinatorial chemistry , crystallography , inorganic chemistry , medicinal chemistry , enzyme , biochemistry , organic chemistry
In this work, four derivatives of the pentaazamacrocyclic Mn‐pyane [pyane = trans ‐2,13‐dimethyl‐3,6,9,12,18‐pentaazabicyclo[12.3.1]‐octadeca‐1(18),14,16‐triene] complex were synthesized and characterized, carrying small substituents at the pyridine ring that allow fine‐tuning of the manganese centered redox potential, without significant change to the overall complex arrangement that is crucial for a correct comparison regarding their superoxide dismutase mimetic (SODm) capabilities. The crystal structure of the seven‐coordinate OMe‐substituted Mn‐pyane complex was obtained. The synthesized complexes will serve for future investigations related to an effect of complex redox potentials on their mechanistic behavior within SOD catalysis.