Premium
The many types of heterogeneity in replicative senescence
Author(s) -
Xu Zhou,
Teixeira Maria Teresa
Publication year - 2019
Publication title -
yeast
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.923
H-Index - 102
eISSN - 1097-0061
pISSN - 0749-503X
DOI - 10.1002/yea.3433
Subject(s) - biology , senescence , telomere , genome instability , saccharomyces cerevisiae , organism , microbiology and biotechnology , cellular senescence , genetics , longevity , model organism , phenotype , dna damage , gene , dna
Replicative senescence, which is induced by telomere shortening, underlies the loss of regeneration capacity of organs and is ultimately detrimental to the organism. At the same time, it is required to protect organisms from unlimited cell proliferation that may arise from numerous stimuli or deregulations. One important feature of replicative senescence is its high level of heterogeneity and asynchrony, which promote genome instability and senescence escape. Characterizing this heterogeneity and investigating its sources are thus critical to understanding the robustness of replicative senescence. Here we review the different aspects of senescence driven by telomere attrition that are subject to variation in Saccharomyces cerevisiae , the current understanding of the molecular processes at play, and the consequences of heterogeneity in replicative senescence.