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An overview of pre‐ribosomal RNA processing in eukaryotes
Author(s) -
Henras Anthony K.,
PlissonChastang Célia,
O'Donohue MarieFrançoise,
Chakraborty Anirban,
Gleizes PierreEmmanuel
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: rna
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.225
H-Index - 71
eISSN - 1757-7012
pISSN - 1757-7004
DOI - 10.1002/wrna.1269
Subject(s) - ribosome biogenesis , ribosomal rna , 5.8s ribosomal rna , biology , eukaryotic ribosome , ribosome , ribosomal protein , rna , small nucleolar rna , eukaryotic large ribosomal subunit , genetics , eif4a , computational biology , non coding rna , 18s ribosomal rna , microbiology and biotechnology , gene
Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms. In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne by a long polycistronic pre‐ribosomal RNA . A complex sequence of processing steps is required to gradually release the mature RNAs from this precursor, concomitant with the assembly of the 79 ribosomal proteins. A large set of trans ‐acting factors chaperone this process, including small nucleolar ribonucleoparticles. While yeast has been the gold standard for studying the molecular basis of this process, recent technical advances have allowed to further define the mechanisms of ribosome biogenesis in animals and plants. This renewed interest for a long‐lasting question has been fueled by the association of several genetic diseases with mutations in genes encoding both ribosomal proteins and ribosome biogenesis factors, and by the perspective of new anticancer treatments targeting the mechanisms of ribosome synthesis. A consensus scheme of pre‐ribosomal RNA maturation is emerging from studies in various kinds of eukaryotic organisms. However, major differences between mammalian and yeast pre‐ribosomal RNA processing have recently come to light. WIREs RNA 2015, 6:225–242. doi: 10.1002/wrna.1269 This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes RNA Processing > rRNA Processing RNA in Disease and Development > RNA in Disease