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Amylose engineering: phosphorylase‐catalyzed polymerization of functional saccharide primers for glycobiomaterials
Author(s) -
Nishimura Tomoki,
Akiyoshi Kazunari
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1423
Subject(s) - amylose , biocompatibility , context (archaeology) , hybrid , chemistry , polymerization , polymer , nanotechnology , materials science , combinatorial chemistry , chemical engineering , biochemistry , organic chemistry , biology , starch , engineering , botany , paleontology
Interest in amylose and its hybrids has grown over many decades, and a great deal of work has been devoted to developing methods for designing functional amylose hybrids. In this context, phosphorylase‐catalyzed polymerization shows considerable promise as a tool for preparing diverse amylose hybrids. Recently, advances have been made in the chemoenzymatic synthesis and characterization of amylose‐ block ‐polymers, amylose‐ graft ‐polymers, amylose‐modified surfaces, hetero‐oligosaccharides, and cellodextrin hybrids. Many of these saccharides provide clear opportunities for advances in biomaterials because of their biocompatibility and biodegradability. Important developments in bioapplications of amylose hybrids have also been made, and such newly developed amylose hybrids will help promote the development of new generations of glyco materials. WIREs Nanomed Nanobiotechnol 2017, 9:e1423. doi: 10.1002/wnan.1423 This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology