Open AccessConcise Review: Stem Cells for the Treatment of Cerebellar‐Related Disorders
Author(s) -
Erceg Slaven,
MorenoManzano Victoria,
GaritaHernandez Marcela,
Stojkovic Miodrag,
Bhattacharya Shomi S.
Publication year - 2011
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.619
Subject(s) - biology , embryonic stem cell , induced pluripotent stem cell , stem cell , neuroscience , neural stem cell , progenitor cell , cerebellum , cell therapy , transplantation , microbiology and biotechnology , genetics , medicine , gene
Embryonic neural transplants have become clinically relevant over the past 25 years for their possible application in the treatment of cerebellum‐related neurodegenerative diseases. While highlighting the important role that fetal neural progenitors have in meeting these challenges, we define rationales for all types of cell therapy involving adult stem cells as well as human embryonic stem cells (hESC) and human induced pluripotent stem (iPS) cells. The recent advances in the field of hESC and iPS cells, including their capacity for differentiation toward regional specific neural lineages, could open a new era of transplantation in cell‐based therapy for cerebellar ataxias. S TEM C ells 2011;29:564–569