Open AccessEcological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis
Author(s) -
Su Yingying,
Chen Chider,
Guo Lijia,
Du Juan,
Li Xiaoyan,
Liu Yi
Publication year - 2018
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.2762
Subject(s) - mesenchymal stem cell , biology , microbiome , oral microbiome , stem cell , immunology , homeostasis , regeneration (biology) , microbiology and biotechnology , bioinformatics
Oral microbiome is essential for maintenance of oral cavity health. Imbalanced oral microbiome causes periodontal and other diseases. It is unknown whether oral microbiome affect oral stem cells function. This study used a common clinical antibiotic treatment approach to alter oral microbiome ecology and examine whether oral mesenchymal stem cells (MSCs) are affected. We found that altered oral microbiome resulted gingival MSCs deficiency, leading to a delayed wound healing in male mice. Mechanistically, oral microbiome release lipopolysaccharide (LPS) that stimulates the expression of microRNA‐21 (miR‐21) and then impair the normal function of gingival MSCs and wound healing process through miR‐21/Sp1/telomerase reverse transcriptase pathway. This is the first study indicate that interplay between oral microbiome and MSCs homeostasis in male mice. S tem C ells 2018;36:551–561