Open AccessMultiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma
Author(s) -
Rennert Robert C.,
Achrol Achal S.,
Januszyk Michael,
Kahn Suzana A.,
Liu Tiffany T.,
Liu Yi,
Sahoo Debashis,
Rodrigues Melanie,
Maan Zeshaan N.,
Wong Victor W.,
Cheshier Samuel H.,
Chang Steven D.,
Steinberg Gary K.,
Harsh Griffith R.,
Gurtner Geoffrey C.
Publication year - 2016
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.2359
Subject(s) - biology , glioblastoma , brain tumor , single cell analysis , stem cell , gene expression profiling , cancer research , cell , computational biology , gene , gene expression , microbiology and biotechnology , genetics , pathology , medicine
Brain tumor‐initiating cells (BTICs) are self‐renewing multipotent cells critical for tumor maintenance and growth. Using single‐cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single‐cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra‐tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation‐specific therapies. S tem C ells 2016;34:1702–1707