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A bstract   MicroRNA expression profiling in human liver progenitor cells following hepatocytic differentiation identified miR‐122 and miR‐194 as the microRNAs most strongly upregulated during hepatocytic differentiation of progenitor cells. MiR‐194 was also highly upregulated following hepatocytic differentiation of human embryonic stem cells (hESCs). Overexpression of miR‐194 in progenitor cells accelerated their differentiation into hepatocytes, as measured by morphological features such as canaliculi and expression of hepatocytic markers. Overexpression of miR‐194 in hESCs induced their spontaneous differentiation, a phenotype accompanied with accelerated loss of the pluripotent factors  OCT4  and  NANOG  and decrease in mesoderm marker  HAND1  expression. We then identified  YAP1  as a direct target of miR‐194. Inhibition of  YAP1  strongly induced hepatocytic differentiation of progenitor cells and  YAP1  overexpression reversed the miR‐194‐induced hepatocytic differentiation of progenitor cells. In conclusion, we identified miR‐194 as a potent inducer of hepatocytic differentiation of progenitor cells and further identified  YAP1  as a mediator of miR‐194's effects on hepatocytic differentiation and liver progenitor cell fate. S tem  C ells   2016;34:1284–1296

MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP 1