Open AccessConcise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology
Author(s) -
Laplane Lucie,
Beke Allan,
Vainchenker William,
Solary Eric
Publication year - 2015
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.2099
Subject(s) - reprogramming , induced pluripotent stem cell , biology , stem cell , somatic cell , cancer stem cell , microbiology and biotechnology , regenerative medicine , cancer cell , cancer research , computational biology , cancer , cell , embryonic stem cell , genetics , gene
A bstract The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so‐called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. A better understanding of the impact of reprogramming on cancer cell‐specific features as well as improvements in culture conditions to integrate the role of the microenvironment in their behavior may strengthen the epistemic interest of iPS cells as model systems in oncology. S tem C ells 2015;33:2887–2892