Open AccessConcise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration
Author(s) -
Rumman Mohammad,
Dhawan Jyotsna,
Kassem Moustapha
Publication year - 2015
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.2056
Subject(s) - biology , regeneration (biology) , stem cell , microbiology and biotechnology , adult stem cell , cellular differentiation , genetics , gene
A bstract Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle‐arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration. S tem C ells 2015;33:2903—2912