Open AccessMultipotent Glia‐Like Stem Cells Mediate Stress Adaptation
Author(s) -
Rubin de Celis Maria F.,
GarciaMartin Ruben,
Wittig Dierk,
Valencia Gabriela D.,
Enikolopov Grigori,
Funk Richard H.,
Chavakis Triantafyllos,
Bornstein Stefan R.,
AndroutsellisTheotokis Andreas,
EhrhartBornstein Monika
Publication year - 2015
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.2002
Subject(s) - biology , progenitor cell , stem cell , multipotent stem cell , neural stem cell , homeostasis , adult stem cell , adrenal medulla , neuroscience , neural crest , population , nestin , microbiology and biotechnology , cellular differentiation , catecholamine , biochemistry , demography , sociology , gene , embryo
The neural crest‐derived adrenal medulla is closely related to the sympathetic nervous system; however, unlike neural tissue, it is characterized by high plasticity which suggests the involvement of stem cells. Here, we show that a defined pool of glia‐like nestin–expressing progenitor cells in the adult adrenal medulla contributes to this plasticity. These glia‐like cells have features of adrenomedullary sustentacular cells, are multipotent, and are able to differentiate into chromaffin cells and neurons. The adrenal is central to the body's response to stress making its proper adaptation critical to maintaining homeostasis. Our results from stress experiments in vivo show the activation and differentiation of these progenitors into new chromaffin cells. In summary, we demonstrate the involvement of a new glia‐like multipotent stem cell population in adrenal tissue adaptation. Our data also suggest the contribution of stem and progenitor cells in the adaptation of neuroendocrine tissue function in general. S tem C ells 2015;33:2037–2051