Open AccessThe Helix‐Loop‐Helix Protein Id1 Controls Stem Cell Proliferation During Regenerative Neurogenesis in the Adult Zebrafish Telencephalon
Author(s) -
Viales Rebecca Rodriguez,
Diotel Nicolas,
Ferg Marco,
Armant Olivier,
Eich Julia,
Alunni Alessandro,
März Martin,
Bally-Cuif Laure,
Rastegar Sepand,
Strähle Uwe
Publication year - 2015
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.1883
Subject(s) - neurogenesis , biology , neural stem cell , stem cell , zebrafish , microbiology and biotechnology , cerebrum , adult stem cell , cellular differentiation , neuroscience , genetics , gene , central nervous system
The teleost brain has the remarkable ability to generate new neurons and to repair injuries during adult life stages. Maintaining life‐long neurogenesis requires careful management of neural stem cell pools. In a genome‐wide expression screen for transcription regulators, the id1 gene, encoding a negative regulator of E‐proteins, was found to be upregulated in response to injury. id1 expression was mapped to quiescent type I neural stem cells in the adult telencephalic stem cell niche. Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals, suggesting multiple antagonistic pathways in the regulation of reactive neurogenesis. Together, we propose that Id1 acts to maintain the neural stem cell pool by counteracting neurogenesis‐promoting signals. S tem C ells 2015;33:892–903