Open AccessConcise Review: Bridging the Gap: Bone Regeneration Using Skeletal Stem Cell‐Based Strategies—Where Are We Now?
Author(s) -
Dawson Jonathan I.,
Kanczler Janos,
Tare Rahul,
Kassem Moustapha,
Oreffo Richard O.C.
Publication year - 2014
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.1559
Subject(s) - biology , regeneration (biology) , stem cell , regenerative medicine , microbiology and biotechnology , population , bioinformatics , medicine , environmental health
Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone regeneration strategies seek to harness and enhance this regenerative capacity for the replacement of tissue damaged or lost through congenital defects, trauma, functional/esthetic problems, and a broad range of diseases associated with an increasingly aged population. This review describes the state of the field and current steps to translate and apply skeletal stem cell biology in the clinic and the problems therein. Challenges are described along with key strategies including the isolation and ex vivo expansion of multipotential populations, the targeting/delivery of regenerative populations to sites of repair, and their differentiation toward bone lineages. Finally, preclinical models of bone repair are discussed along with their implications for clinical translation and the opportunities to harness that knowledge for musculoskeletal regeneration. S tem C ells 2014;32:35–44