Premium
Hollow Structure Improved Anti‐Cancer Immunity of Mesoporous Silica Nanospheres In Vivo
Author(s) -
Wang Xiupeng,
Li Xia,
Ito Atsuo,
Yoshiyuki Kazuko,
Sogo Yu,
Watanabe Yohei,
Yamazaki Atsushi,
Ohno Tadao,
Tsuji Noriko M.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201600677
Subject(s) - in vivo , mesoporous silica , mesoporous material , nanotechnology , immunity , cancer , in vitro , materials science , splenocyte , cancer immunotherapy , chemistry , immunotherapy , biology , immune system , immunology , biochemistry , microbiology and biotechnology , catalysis , genetics
Hollow and non‐hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants. The hollow structure of mesoporous silica nanospheres significantly promote cellular uptake of a model cancer antigen by macrophage‐like cells in vitro, improve anti‐cancer immunity, CD4 + and CD8 + T cell populations in splenocytes of mice in vivo.