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Escalation, group and A + B designs for dose‐finding trials
Author(s) -
Ivanova Anastasia
Publication year - 2006
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2470
Subject(s) - outcome (game theory) , clinical trial , construct (python library) , maximum tolerated dose , computer science , medicine , statistics , econometrics , mathematics , mathematical economics , programming language
In this paper, rules are given on how to construct escalation, A + B, and group designs for dose‐finding trials. Operational characteristics of these designs are discussed and compared via simulations. Dose‐finding designs for trials with ordinal toxicity outcome are considered. Copyright © 2005 John Wiley & Sons, Ltd.
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