Open AccessLongitudinal neuroimaging evaluation of the corticospinal tract in patients with stroke treated with autologous bone marrow cells
Author(s) -
Haque Muhammad E.,
Hasan Khader M.,
George Sarah,
Sitton Clark,
Boren Seth,
Arevalo Octavio D.,
Vahidy Farhaan,
Zhang Xu,
Cox Charles S.,
Alderman Susan,
Aronowski Jaroslaw,
Grotta James C.,
Savitz Sean I.
Publication year - 2021
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.20-0369
Subject(s) - corona radiata (embryology) , medicine , corticospinal tract , internal capsule , fractional anisotropy , stroke (engine) , diffusion mri , pons , surgery , pathology , white matter , radiology , magnetic resonance imaging , mechanical engineering , ovarian follicle , hormone , cumulus oophorus , engineering
Bone marrow mononuclear cells (MNCs) attenuate secondary degeneration and enhance recovery in stroke animal models. In a nonrandomized clinical trial, we imaged 37 patients with stroke: 17 patients treated with MNCs (treated) and 20 patients who received standard of care (nontreated) at 1, 3, and 12 months onset of stroke on 3.0T MRI system. Three‐dimensional anatomical and diffusion tensor images were obtained. The integrity of the corticospinal tract was assessed by measuring absolute and relative fractional anisotropy (FA) and mean diffusivity (MD) in the rostral pons (RP), posterior limb of the internal capsule, and corona radiata by drawing regions of interest. Infarct volume and stroke severity, which was assessed via the NIH Stroke Scale (NIHSS), were higher in the MNC group compared with the nontreated patients, which is a major limitation. Overall, the relative FA (rFA) of the nontreated patients exhibited continued reduction and an increase in relative MD (rMD) from 1 to 12 months, whereas despite larger infarcts and higher severity, treated patients displayed an increase in rFA from 3 to 12 months and no change in rMD. Contrary to the nontreated group, the treated patients' rFA was also significantly correlated ( P < .05) with NIHSS score in the RP at all time points, whereas rMD at the last two.