Open AccessConcise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair
Author(s) -
Witjas Franca M. R.,
van den Berg Bernard M.,
van den Berg Cathelijne W.,
Engelse Marten A.,
Rabelink Ton J.
Publication year - 2019
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.18-0155
Subject(s) - decellularization , extracellular matrix , microbiology and biotechnology , regenerative medicine , stem cell , homeostasis , matrix (chemical analysis) , tissue engineering , biology , signal transduction , chemistry , genetics , chromatography
All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano‐, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. Stem Cells Translational Medicine 2019;8:375–382