Open AccessConcise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell‐Derived Blood Cells— Ready for Take‐Off
Author(s) -
Haake Kathrin,
Ackermann Mania,
Lachmann Nico
Publication year - 2019
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.18-0134
Subject(s) - induced pluripotent stem cell , reprogramming , regenerative medicine , stem cell , translation (biology) , computational biology , translational medicine , clinical trial , medicine , neuroscience , bioinformatics , biology , embryonic stem cell , cell , microbiology and biotechnology , pathology , genetics , messenger rna , gene
Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have opened up a world of possibilities for regenerative medicine and novel cell‐based therapeutics. Now, over a decade later, robust reprogramming and expansion and differentiation protocols have been developed, and iPSC‐derived cells have been used in a wide variety of small and large animal models to treat many different diseases. Furthermore, the first iPSC derivatives are on their way into clinical trials. In this line, (i) GMP‐compliant generation, cultivation, and differentiation, (ii) preclinical efficacy and safety, as well as (iii) ethical and regulatory compliance of stem cell research represent important aspects that need to be evaluated for proper clinical translation of iPSCs and their derivatives. In this review article, we provide an overview of the current advances and challenges of the clinical translation of iPSC‐derived blood cells and highlight the most pressing problems that have to be overcome in the next years. Stem Cells Translational Medicine 2019;8:332–339