Open AccessConcise Review: Fat and Furious: Harnessing the Full Potential of Adipose‐Derived Stromal Vascular Fraction
Author(s) -
Dykstra Jordan A.,
Facile Tiffany,
Patrick Ryan J.,
Francis Kevin R.,
Milanovich Samuel,
Weimer Jill M.,
Kota Daniel J.
Publication year - 2017
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.16-0337
Subject(s) - stromal vascular fraction , regenerative medicine , adipose tissue , stem cell , paracrine signalling , medicine , stromal cell , mesenchymal stem cell , population , bioinformatics , neuroscience , disease , biology , pathology , microbiology and biotechnology , receptor , environmental health
Due to their capacity to self‐renew, proliferate and generate multi‐lineage cells, adult‐derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer's disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose‐derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose‐derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications. S tem C ells T ranslational M edicine 2017;6:1096–1108