Open AccessThrombosis and coagulopathy in COVID‐19: An illustrated review
Author(s) -
Levi Marcel,
Hunt Beverley J.
Publication year - 2020
Publication title -
research and practice in thrombosis and haemostasis
Language(s) - English
Resource type - Journals
ISSN - 2475-0379
DOI - 10.1002/rth2.12400
Subject(s) - coagulopathy , medicine , covid-19 , thrombosis , inflammation , disseminated intravascular coagulation , coronavirus , venous thrombosis , intensive care medicine , pulmonary embolism , coagulation , disease , immunology , pathology , infectious disease (medical specialty) , outbreak
This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID‐19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute‐phase proteins, very high levels of D‐dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID‐19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).