Open AccessHemostatic complications associated with ventricular assist devices
Author(s) -
Hilal Talal,
Mudd James,
DeLoughery Thomas G.
Publication year - 2019
Publication title -
research and practice in thrombosis and haemostasis
Language(s) - English
Resource type - Journals
ISSN - 2475-0379
DOI - 10.1002/rth2.12226
Subject(s) - medicine , hemostasis , intensive care medicine , von willebrand factor , thrombosis , pathophysiology , platelet , coagulation , von willebrand disease , heparin , disease , cardiology , surgery
Hemostatic complications are common in patients with ventricular assist devices. The pathophysiologic mechanisms that lead to dysregulated hemostasis involve complex interactions between device surface, sheer stress, and blood flow. These factors lead to various manifestations that require a thorough understanding of the interplay among platelets, coagulation factors, and red cells. In this article, we review the pathophysiology of hematologic complications (bleeding, acquired von Willebrand disease, heparin‐induced thrombocytopenia, hemolysis, stroke and pump thrombosis), the clinical manifestations, and the management of each. We summarize the evidence available for management of these entities and provide a pragmatic clinical review.