Open AccessAdvanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination
Author(s) -
Tatsumi Takayuki,
Ishida Eri,
Tatsumi Kuniko,
Okada Yumiko,
Saito Takakazu,
Kubota Toshiro,
Saito Hidekazu
Publication year - 2018
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1002/rmb2.12222
Subject(s) - pregnancy , paternal age , live birth , intrauterine insemination , medicine , sperm , assisted reproductive technology , obstetrics , advanced maternal age , confounding , pregnancy rate , insemination , gynecology , affect (linguistics) , artificial insemination , andrology , infertility , biology , offspring , fetus , psychology , genetics , communication
Purpose This study aimed to evaluate the effect of advanced paternal age on pregnancy outcomes and sperm parameters following intrauterine insemination ( IUI ). We used IUI data rather than assisted reproductive technology data, which might mask the effects of sperm impairments. Methods We retrospectively analyzed 1576 IUI cycles in women under 40 years old between April 2012 and May 2016 at the National Center for Child Health and Development in Japan. The main outcomes were clinical pregnancy and live birth. Results The mean male age was significantly lower in cycles that resulted in pregnancy compared with those without pregnancy (38.0 vs 39.1 years; P < 0.001), with a similar trend for live‐birth cycles. However, there was no relationship between advanced paternal age and pregnancy outcomes after adjusting for confounding factors and correlations within patients using generalized estimating equations, and the age of the female partner was the only factor affecting pregnancy rate. Furthermore, advanced paternal age had no effect on sperm parameters. Conclusions Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following IUI .