Open AccessEvaluation of transfer media containing different concentrations of hyaluronan for human in vitro fertilization
Author(s) -
Nishihara Takuji,
Morimoto Yoshiharu
Publication year - 2017
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1002/rmb2.12051
Subject(s) - embryo transfer , blastocyst , andrology , in vitro fertilisation , embryo , gynecology , blastocyst transfer , pregnancy , human fertilization , abortion , pregnancy rate , medicine , chemistry , biology , embryogenesis , anatomy , genetics , microbiology and biotechnology
Purpose The aim of the present prospective study was to investigate the efficacy of hyaluronan ( HA ) using two different concentrations as embryo transfer media for in vitro fertilization embryo transfer cycles. Methods A total of 169 cycles undergoing fresh embryo transfer on day 2 or 3, 561 cycles undergoing frozen‐thawed embryo transfer on day 2 or 3, and 484 cycles of frozen‐thawed blastocyst transfer were included in this study. Patients were randomly divided into two groups: transferred with low (l‐ HA ) or high (h‐ HA ) concentrations of HA in transfer media. Results In the case of fresh embryo transfer cycles, no significant differences were observed in the pregnancy (l‐ HA 27.2%, h‐ HA 31.2%), implantation (l‐ HA 22.1%, h‐ HA 24.2%), or abortion (l‐ HA 24.0%, h‐ HA 20.8%) rates between the two groups. In the case of frozen‐thawed embryo transfer cycles, no significant differences were noted in the pregnancy (l‐ HA 20.9%, h‐ HA 22.9%), implantation (l‐ HA 13.4%, h‐ HA 15.8%), or abortion (l‐ HA 17.2%, h‐ HA 21.5%) rates. In the case of frozen‐thawed blastocyst transfer cycles, no significant differences were observed in the pregnancy (l‐ HA 46.0%, h‐ HA 41.8%), implantation (l‐ HA 45.8%, h‐ HA 41.3%), or abortion (l‐ HA 17.6%, h‐ HA 26.9%) rates. Conclusion The present results showed that pregnancy, implantation, and abortion rates with transfer media containing different HA concentrations were similar.