Open AccessLeydig cell tumor of the testis, presenting with azoospermia
Author(s) -
Hibi Hatsuki,
Yamashita Kyoko,
Sumitomo Makoto,
Asada Yoshimasa
Publication year - 2017
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1002/rmb2.12046
Subject(s) - azoospermia , luteinizing hormone , testosterone (patch) , medicine , follicle stimulating hormone , spermatogenesis , leydig cell , hormone , leydig cell tumor , endocrinology , orchiectomy , andrology , urology , infertility , biology , pregnancy , genetics
Case A case of Leydig cell tumor, associated with azoospermia, is presented. Outcome The levels of sex hormones obviously were decreased, including luteinizing hormone ( LH ) and follicle‐stimulating hormone ( FSH ), with elevated testosterone. Computed tomography revealed no adrenal gland tumor, but a significant calcification in the right scrotal content was observed. He received a right radical orchiectomy and then he was unable to ejaculate. An endocrine panel revealed significantly decreased levels of testosterone and the low LH level had remained. Hormone replacement therapy with combined LH and FSH successfully recovered and preserved spermatogenesis. Conclusions Although the patient’s sexual function deteriorated after surgery, hormone replacement therapy was successful in establishing spermatogenesis.