Open AccessEfficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two‐centers study
Author(s) -
Hashimoto Tomoko,
Koizumi Masae,
Doshida Masakazu,
Toya Mayumi,
Sagara Eri,
Oka Nao,
Nakajo Yukiko,
Aono Nobuya,
Igarashi Hideki,
Kyono Koichi
Publication year - 2017
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1002/rmb2.12041
Subject(s) - medicine , pregnancy , embryo transfer , gynecology , endometrium , retrospective cohort study , pregnancy rate , reproductive medicine , obstetrics , surgery , genetics , biology
Aim This study aimed to assess the efficacy of the endometrial receptivity array ( ERA ) as a diagnostic tool and the impact of personalized embryo transfer ( pET ) for the treatment of patients with recurrent implantation failure ( RIF ) in Japan. Methods Fifty patients with a history of RIF with frozen‐thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling for the ERA and histological dating and a pET according to the ERA were performed. The receptive (R) or non‐receptive ( NR ) status of the endometrium as a result of the first ERA , endometrial dating, and pregnancy rates after the pET were analyzed. Results Of the patients with RIF , 12 (24%) were NR . Among them, eight (66.7%) were prereceptive. A clinical follow‐up was possible in 44 patients who underwent the pET . The pregnancy rates were 58.8% per patient and 35.3% per first pET in the R patients and 50.0% per patient and 50.0% per first pET in the NR patients. Discrepancies between the ERA results and histological dating were seen more in the NR patients than in the R patients. Conclusions For patients with unexplained RIF , there is a significance in searching for their personal window of implantation ( WOI ) using the ERA , considering the percentage of those who were NR and the pregnancy rates that resulted from the pET . By transferring euploid embryos in a personal WOI , much better pregnancy rates are expected.