English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aim  This study evaluated the efficacy and safety of vaginal progesterone gel that was administered daily for luteal phase support as part of in vitro fertilization/embryo transfer ( IVF / ET ) cycles in Japanese women.    Methods  This was a phase  III , multicenter, open‐label, single‐arm trial in Japanese women undergoing  IVF / ET , using the Japanese Society of Obstetrics and Gynecology 2009 registry as a historical control. The primary objective was to demonstrate the non‐inferiority, with regard to the clinical pregnancy rate per  ET , of vaginal progesterone gel that was administered once daily, compared with the historical standard value in  IVF / ET  cycles in Japan. The biochemical pregnancy (positive serum β‐ hCG  pregnancy test but no clinical pregnancy) rate per  ET  also was investigated, as were the safety and tolerability of the vaginal progesterone gel.    Results  Of the 178 women who were enrolled, 123 underwent  IVF / ET . The clinical pregnancy rate per  ET  was non‐inferior in the prospective arm, compared with the historical population. The biochemical pregnancy rate per  ET  was 7.3%. The safety profile of the vaginal progesterone gel was as expected, with no new safety issue identified.    Conclusion  The vaginal progesterone gel was efficacious, with a safety profile as expected, in this study in Japanese women undergoing  IVF / ET  cycles.

reproductive medicine and biology

Phase  III  trial of 8% vaginal progesterone gel for luteal phase support in Japanese women undergoing in vitro fertilization and fresh embryo transfer cycles