Open AccessH enoch– S chonlein purpura in mesothelioma
Author(s) -
Joshi Stuti,
Pillai Sooraj,
Chakera Aron,
Lee Y. C. Gary
Publication year - 2014
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.78
Subject(s) - medicine , henoch schonlein purpura , purpura (gastropod) , proteinuria , mesothelioma , malignancy , nephropathy , renal biopsy , glomerulonephritis , pathology , gastroenterology , vasculitis , biopsy , kidney , disease , ecology , diabetes mellitus , biology , endocrinology
H enoch– S chonlein purpura ( HSP ) is primarily a childhood immunoglobulin A ( IgA )‐mediated illness. When adults are affected, malignancy can be associated. We present a rare case of HSP in a 75‐year‐old man with malignant pleural mesothelioma. He presented with episodes of dizziness and subsequently developed non‐palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment. HSP was diagnosed based on clinical and histological findings on biopsy specimens from the skin and kidney that showed a leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis with IgA deposits, respectively. He was treated with high‐dose oral steroids with resolution of the skin and renal manifestations of the disease. HSP is rare in adults but has been linked to cancers. This is the first report of HSP in a patient with known malignant pleural mesothelioma.