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Prophylactic and Therapeutic Effects of Acanthopanax senticosus Harms Extract on Murine Collagen‐induced Arthritis
Author(s) -
Takahashi Yusuke,
Tanaka Maki,
Murai Ryosei,
Kuribayashi Kageaki,
Kobayashi Daisuke,
Yanagihara Nozomi,
Watanabe Naoki
Publication year - 2014
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.5157
Subject(s) - medicine , arthritis , rheumatoid arthritis , therapeutic effect , peripheral blood mononuclear cell , traditional medicine , antibody , pharmacology , immunology , in vitro , biology , biochemistry
Evidences are accumulating that extract of Acanthopanax senticosus Harms (ASH; syn Eleutherococcus senticosus [Rupr. & Maxim.] Maxim), a shrub native to Northeastern Asia, has antiinflammatory effects. In this study, we examined prophylactic and therapeutic effects of ASH extract (ASHE) on rheumatoid arthritis using collagen‐induced arthritis (CIA) mouse model. Acanthopanax senticosus Harms extract was administered before the onset of arthritis in the prophylaxis model. In the therapeutic model, ASHE was administered after the onset of arthritis with or without anti‐TNF‐α antibody. The ASHE treatment showed efficacy before onset of CIA but there was no effect after CIA was established. The ASHE treatment delayed the onset and decreased severity of CIA. In vitro examinations showed that ASHE is an antioxidant and that ASHE suppresses TNF‐α and interleukin‐6 production in human peripheral blood mononuclear cells. The combination therapy with ASHE and anti‐TNF‐α antibody reduced the severity of arthritis compared with anti‐TNF‐α antibody alone. The present study shows that ASHE has prophylactic effect against CIA and support therapeutic effect of anti‐TNF‐α antibody. © 2014 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.