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A new approach to understand the time‐dependent temperature increasing process of gold‐silica core‐shell nanoparticles injected into chicken tissues under near‐infrared laser irradiation is proposed. Gold nanoshells strongly absorb near‐infrared radiations and efficiently transform absorbed energy into heat. Temperature rise given by experiments and numerical calculations based on bioheat transfer are in good agreement. Our work improves the analysis of a recent study [Richardson et al.,  Nano Lett .  2009 ,  9 , 1139] by including effects of the medium perfusion on temperature increase. The theoretical analysis can also be used to estimate the distribution of nanoparticles in experimental samples and provide a relative accuracy prediction for the temperature profile of new systems. This methodology provides a novel and reliable tool for speeding up photothermal investigations and designing state‐of‐the‐art photothermal devices.

Near‐Infrared Photothermal Response of Plasmonic Gold‐Coated Nanoparticles in Tissues