Open AccessPharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development
Author(s) -
Swat MJ,
Moodie S,
Wimalaratne SM,
Kristensen NR,
Lavielle M,
Mari A,
Magni P,
Smith MK,
Bizzotto R,
Pasotti L,
Mezzalana E,
Comets E,
Sarr C,
Terranova N,
Blaudez E,
Chan P,
Chard J,
Chatel K,
Chenel M,
Edwards D,
Franklin C,
Giorgino T,
Glont M,
Girard P,
Gre P,
Harling K,
Hooker AC,
Kaye R,
Keizer R,
Kloft C,
Kok JN,
Kokash N,
Laibe C,
Laveille C,
Lestini G,
Mentré F,
Munafo A,
Nordgren R,
Nyberg HB,
ParraGuillen ZP,
Plan E,
Ribba B,
Smith G,
Trocóniz IF,
Yvon F,
Milligan PA,
Harnisch L,
Karlsson M,
Hermjakob H,
Le Novère N
Publication year - 2015
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.57
Subject(s) - computer science , markup language , workflow , reuse , drug development , software engineering , data exchange , encode , quality (philosophy) , data science , xml , drug , world wide web , database , medicine , engineering , pharmacology , philosophy , epistemology , gene , waste management , biochemistry , chemistry
The lack of a common exchange format for mathematical models in pharmacometrics has been a long‐standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps.