Open AccessA Tutorial on Target‐Mediated Drug Disposition (TMDD) Models
Author(s) -
Dua P,
Hawkins E,
van der Graaf PH
Publication year - 2015
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.41
Subject(s) - disposition , drug , computational biology , computer science , pharmacokinetics , chemistry , pharmacology , medicine , biology , epistemology , philosophy
Target‐mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics.[1][Levy, G., 1994] The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers. Examples of Berkeley Madonna[2][Krause, A., 2014] code for some models discussed in this Tutorial are provided in the Supplementary Materials.