Open AccessReproducing prolonged time to peak bisoprolol concentration by PBPK modeling with lysosomal trapping in enterocytes
Author(s) -
Wu DanNa,
Yu Guo,
Li GuoFu
Publication year - 2022
Publication title -
cpt: pharmacometrics and systems pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 37
ISSN - 2163-8306
DOI - 10.1002/psp4.12756
Subject(s) - physiologically based pharmacokinetic modelling , bisoprolol , pharmacokinetics , cmax , gastric emptying , chemistry , pharmacology , stomach , medicine , biochemistry , heart failure